The CyberKnife Robotic Radiosurgery System is a non-invasive alternative to surgery for the treatment of both cancerous and non-cancerous tumors anywhere in the body, including the prostate, lung, brain, spine, liver, pancreas and kidney. The treatment – which delivers high doses of radiation to tumors with extreme accuracy – offers new hope to patients who have inoperable or surgically complex tumors, or who may be looking for a non-surgical option. Three basic characteristics are important for patient selection in Cyberknife similar to other radiosurgery applications. Firstly, patients should have reasonable overall survival after radiosurgery treatment. Benign lesions are in this group and are easily treated with radiosurgery. Patients who have malign tumors and expected life is more than 6 months could be treated with radiosurgery. Secondly, capacity of patient cooperation to all diagnostic and treatment stages is important. Treatment time takes longer for patients who do not have complete cooperation. At last, patients whose tumor borders are clearly verified with radiological scans are good candidates for radiosurgery treatment.